Organic A2 Whole Milk Powder

More than 99% of β - casein in A2 organic milk powder is A2 β - casein. β - casein is a major casein, accounting for about 30% of the total milk protein ^[1], which is mainly manifested in two gene variants: type A1 and type A2. The former is the product of gene mutation, while the latter is considered to be the original β - casein genotype. β - casein is composed of 209 amino acids. Because of the difference of gene, A1 or A2, the difference is the 67th amino acid in the protein chain.(Fig. 1)

The slight difference in the structure of the two β - caseins means that they are also absorbed differently. Through the action of digestive enzymes, A1 β - casein may produce β - casein-7 (bcm-7) (Fig. 2), an exogenous opioid peptide ^[2][3][4][5]. On the contrary, in the case of normal intestinal absorption ^{[3] [4] [5] [6]}, the release of bcm-7 from A2 β - casein may be very small, and it is likely that the release will be reduced to the lowest level, because A2 β - casein "(66) is different image.png Leucine - (67) proline bond is not easy to enzymolysis or the probability of occurrence is very low^[2].

Published scientific research shows that A2 Whole Milk Powder has the following effects：

   ·Milk containing total A2 β - casein can help some people with digestive tract discomfort (PD3) after intake of dairy products ^[7]
   ·Reducing bovine β - casein-7 intake ^[2]
   ·Reduce the inflammatory response caused by β - tyrphin-7 ^[8]
   ·Reduce mental retardation and other mental diseases caused by β - tyrphin-7, such as autism ^{[9] [10]}

Status:

Functions:

Mechanism of Action：

Organic A2 Whole Milk Powder can promote human health in a variety of ways, including:


   ·Reduce the production of β - tyrophin-7 ^[2]
   ·Closer to breast milk ingredients, more compatible with human body ^[2]

Safety：

Safety is crucial for vulnerable groups (such as the elderly and infants). Oral toxicity tests and a large number of clinical studies have confirmed the safety of A2 whole milk powder, and no adverse reactions were found among the subjects ^[11]. A2 whole milk powder has always been safe. It has been certified by FDA gras in food application and infant formula.

[1] Walstra P , Jenness R . Dairy chemistry and physics[M]. Wiley, 1984.

[2] European, Food, Safety, et al. Review of the potential health impact of β-casomorphins and related peptides[J]. Efsa Journal, 2009.

[3] Noni I D , Cattaneo S . Occurrence of β-casomorphins 5 and 7 in commercial dairy products and in their digests following in vitro simulated gastro-intestinal digestion[J]. Food Chemistry, 2010, 119(2):560-566.

[4] Noni I D . Release of β-casomorphins 5 and 7 during simulated gastro-intestinal digestion of bovine β-casein variants and milk-based infant formulas[J]. Food Chemistry, 2008, 110(4):897-903.

[5] Jinsmaa Y , Yoshikawa M . Enzymatic release of neocasomorphin and beta-casomorphin from bovine beta-casein.[J]. Peptides, 1999, 20(8):957.

[6] Schmelzer C E H , Sch?Ps R , Reynell L , et al. Peptic digestion of beta-casein. Time course and fate of possible bioactive peptides.[J]. Journal of Chromatography A, 2007, 1166(1-2):108-115.

[7] Jianqin S, Leiming X, Lu X et al.Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cow’s milk. Nutr J, 2016,15 (1):35.

[8] Mohammad Raies Ul Haq, Rajeev Kapila, Rohit Sharma,等. Comparative evaluation of cow β-casein variants (A1/A2) consumption on Th2-mediated inflammatory response in mouse gut[J]. European Journal of Nutrition, 2013.

[9] Kost N V , Sokolov O Y , Kurasova O B , et al. Beta-casomorphins-7 in infants on different type of feeding and different levels of psychomotor development.[J]. Peptides, 2009, 30(10):1854-1860.

[10] Barnett M P G , Mcnabb W C , Roy N C , et al. Dietary A1 β -casein affects gastrointestinal transit time, dipeptidyl peptidase-4 activity, and inflammatory status relative to A2 β -casein in Wistar rats[J]. International Journal of Food ences & Nutrition, 2014.

[11] Swinburn B . Beta case in A1 and A2 in milk and human health[J]. New Zealand Food Safety Authority, 2004.