Bifidobacterium breve M-16V^®

Bifidobacterium is a well studied and beneficial bacterium, which naturally exists in human intestine. There are many kinds of bifidobacteria, and like other kinds of probiotics, different strains have different health effects.

Bifidobacterium breve is one of bifidobacteria, which is usually found in the intestines of newborn infants. M-16V ^® It is a stable Bifidobacterium breve strain at room temperature, supported by more than 30 published academic studies, including 19 human clinical trials. It has special benefits for low birth weight babies. In fact, the M-16V ^® It is used for low birth weight infants in neonatal intensive care units in about 100 hospitals in Japan.

Published scientific studies show that the M-16V ^® In children or infants, including low birth weight infants, they have the following functions:

   ·Recover Bifidobacterium to normal level ^{[1] [2] [3]}
   ·Support healthy immune system ^[4]
   ·Promote respiratory health ^{[5] [6]}
   ·Support skin health ^{[7] [8]} 

Status：

Functions：

Mechanism：

M-16V ^® There are many ways to protect the health of children and infants, including:

   ·Support the health of gastrointestinal mucosa ^{[9] [10]}

   ·It regulates immune response by acting on T helper cells, immunoglobulin E and galectin-9 ^{[11] [12]}

Safety：

Safety is critical for medically vulnerable groups, such as premature or low birth weight infants. Bifidobacteria naturally exist in human intestines and are related to health. Oral toxicity test, antibiotic resistance analysis, genomic analysis and a large number of clinical studies have confirmed the safety of Senyong M-16V ^®, and no adverse reactions were found among the subjects ^{[13] [14]}. Senyong M-16V has always been safe. It has been certified by FDA gras in food application and infant formula.

[1] Li Y, et al. Pediatr Int. 2004 Oct;46(5):509-15.

[2] Akiyama K, et al. J Jpn Soc Premat Newborn Med. 1996 Mar;8(1):59-64.

[3] Bennet R, Nord CE, Zetterström R. Acta Paedriat. 1992;81:784-7.

[4] Ezaki S, et al. Allergol Int. 2012 Mar;61(1):107-13.

[5] van der Aa LB, et al. Allergy. 2011 Feb;66(2):170-7.

[6] van de Pol MA, et al. Allergy. 2011 Jan;66(1):39-47

.[7] van der Aa LB, et al. Clin Exp Allergy. 2010 May;40(5):795-804.

[8] Taniuchi S, et al. Journal of Applied Research. 2005;5(2):387-96.

[9] Wang C, et al. J Ped Gastroenterol Nutr. 2007;44:252-7.

[10] Fujii T, et al. J of Ped Gastroenterol. Nutr. 2006 Jul;43:83-88.

[11] Schouten B, et al. J Nutr. 2009 Jul;139(7):1398-403.

[12] de Kivit S, et al. Allergy. 2012 Mar;67(3):343-52.

[13] Abe F, Yaeshima T, Iwatsuki K. Bioscience Microflora. 2009;28(1):7-15.

[14] Abe F, et al. Anaerobe. 2010;16:131-16.