Bacillus coagulans

Bacillus coagulans is a Gram-positive facultative anaerobic nonpathogenic spore forming bacterium. It has strong lactic acid production capacity and is resistant to high temperature, gastric acid and bile salts^[1].


Bacillus coagulans can effectively inhibit the growth of intestinal harmful bacteria in the human body, improve the intestinal micro ecological environment, improve the body's immunity, enhance disease resistance, promote the digestion and absorption of intestinal food, and effectively improve constipation ^[1].

Published scientific research shows that Bacillus coagulans has the following functions in human body:

   ·Treatment of constipation and diarrhea ^[2]
   ·Treatment of abdominal distension and dyspepsia ^[3]
   ·Inhibit and relieve eczema ^{[4] [5]}
   ·Improve immunity ^[6-9]
   ·Inhibiting the growth of harmful bacteria in gastrointestinal tract ^[10-12]
   ·Relieve hand foot mouth pain^[13]

   ·Lower blood glucose ^[14-15]
   ·Reduce blood lipid ^[9]
   ·Promoting nutrient absorption ^[16-20]

Status：

Functions：

Mechanism：

   ·Secrete antibacterial coagulant and lactic acid to inhibit the growth of harmful bacteria ^[10-12]
   ·Secrete lactic acid, repair damaged intestinal mucosa, promote intestinal peristalsis and restore intestinal motility ^[2-3]
   ·Promote the proliferation of beneficial bacteria such as Bifidobacterium and Lactobacillus ^[2-3]
   ·Secrete a variety of enzymes, including amylase, protease, cellulose, etc. ^[16-20]
   ·Activate NK cells, enhance T cell activity, enhance immunity ^[6-9]

Safety：

Safety is crucial for vulnerable groups (such as the elderly and infants). A large number of animal and human clinical studies have confirmed the safety of Bacillus coagulans, and no adverse reactions have been found among the research subjects ^[4-20]. Bacillus coagulans is safe. It has been listed in the list of biological preparations recommended by the European Union safety qualification (QPS) and listed in the list of microorganisms with a history of safe use in food by the International Dairy Federation (IDF). It has been recognized by Gras (substances generally considered safe) of the US food and drug administration. Canada, Australia, New Zealand and other countries have approved its use, which is mainly used in the production and processing of beverages, baked goods, baking mixture, breakfast cereals, candy, etc.

[1] 赵树平, 包维臣, 高鹏飞,等. 凝结芽孢杆菌的特性及研究进展[J]. 家畜生态学报, 2014, 035(002):6-10,20.

[2］DOLIN B J.Effects of a proprietary Bacillus coagulans preparation on symptoms of diarrhea-predominant irrita－ ble bowel syndrome［J］.Methods Find Exp Clin Pharma－ col，2009，31（10）：655-659.

[3] 郭庆丰，陈林，马经纬．凝结芽孢杆菌益生机制及应用研究进展［ Ｊ］食品研究与开发，２０１８，３９ （ １８） ： ２０８－２１３．

[4] 叶翠青. 凝结芽孢杆菌活菌片治疗婴儿湿疹48例疗效观察[J]. 中国实用医药, 2017(18).

[5] 魏明香, 颜荣, 罗海标,等. 凝结芽孢杆菌活菌片治疗婴儿湿疹36例疗效观察[J]. 中国实用儿科杂志, 2010, 25(012):943-945.

[6] Gitte S Jensen, Kathleen F Benson, Steve G Carter, et al. Ganeden－ BC30TM cell wall and metabolites: anti -inflammatory and immune modulating effects in vitro[J]. BMC Immunology, 2010, 11(1): 1-14

[7] Mandel D R, Eichas K, Holmes J. Bacillus coagulans: a viable ad－ junct therapy for relieving symptoms of rheumatoid arthritis accord－ ing to a randomized, controlled trial [J]. BMC Complementary and Alternative Medicine, 2010, 10(1): 1-7

[8] Baron M. A patented strain of Bacillus coagulans increased immune response to viral challenge[J]. Postgraduate Medicine, 2009, 121(2): 114-118

[9] 王文杰, 刘洋, 彭珊瑛, 等. 凝结芽胞杆菌对小鼠免疫功能和粪便胺含量及肠道中氨含量的影响[J]. 中国微生态学杂志, 2006, 18(1): 6-8

[10] Colbère-Garapin F, Martin-Latil S, Blondel B, et al. Prevention and treatment of enteric viral infections: possible benefits of probiotic bacteria[J]. Microbes & Infection, 2007, 9(14): 1623-1631

[11] Ivec M, Boti c T, Koren S, et al. Interactions of macrophages with probiotic bacteria lead to increased antiviral response against vesic－ ular stomatitis virus[J]. Antiviral Research, 2007, 75(3): 266-274

[12] Liu J J, Reid G, Jiang Y, et al. Activity of HIV entry and fusion in－ hibitors expressed by the human vaginal colonizing probiotic Lacto－ bacillus reuteri RC-14[J]. Cellular Microbiology, 2007, 9(1): 120- 130

[13］ 魏红娟，赵红立，任尚申，等.凝结芽孢杆菌活菌制剂在 手足口病中的应用 ［J］. 临床儿科杂志，2012，30（4）： 355-357.

[14] 房志仲, 杨金荣, 李璐, 等. 凝结芽孢杆菌对大鼠降糖作用的实验研 究[J]. 中国微生态学杂志, 2001, 13(5): 257-259.

[15] 房志仲, 李璐, 杨金荣, 等. 凝结芽孢杆菌对免疫功能影响的实验研 究[J]. 中国微生态学杂志, 2005, 17(4): 263-265.

[16] Heck J X, Fl觝res S H, Hertz P F, et al. Optimization of cellulase-free xylanase activity produced by Bacillus coagulans, BL69 in solid - state cultivation[J]. Process Biochemistry, 2005, 40(1): 107-112

[17] Kim Y M, Choi Y J. Studies on the production of beta-galactosidase by Lactobacillus sporogenes Properties and application of beta - glactosidase[J]. Korean Journal of Applied Microbiology & Bioengi－ neering, 1985, 19: 355-360

[18] Asokan S, Jayanthi C. Alkaline protease production by Bacillus licheniformis and Bacillus coagulans[J]. Journal of Cell and Tissue Research, 2010, 10(1): 2119-2123

[19] Kanwar S S, Ghazi I A, Chimni S S, et al. Purification and properties of a novel extra -cellular thermotolerant metallolipase of Bacillus coagulans, MTCC-6375 isolate[J]. Protein Expression and Purifica－ tion, 2006, 46(2): 421-428

[20] Ou M S, Ingram L O, Shanmugam K T. L (+)-Lactic acid production from non-food carbohydrates by thermotolerant Bacillus coagulans[J]. Journal of Industrial Microbiology & Biotechnology, 2011, 38 (5): 599-609